资深警探具仁浩队长（宋康昊 饰）收到一宗飞机恐怖袭击的情报，调查期间却发现疑犯柳镇锡（任时完 饰）早已秘密登机，更惊觉爱妻亦登上了同一航班，使他倍感担忧。柳镇锡于三万呎高空中散播生化病毒，令乘客逐一离奇死亡，虽然被患有飞机恐惧症的暖心爸爸朴在赫（李秉宪 饰）成功制伏，但已无法阻止致命病毒在机上传播。此时，以国土交通部部长金淑姬（全度妍 饰）为首的应变中心迅速成立，可惜各政府部门联手后还是无计可施…… 幸存的150名乘客被困机舱，惨变生化炸弹，同时机上燃料随时耗尽，机上众人生命危在旦夕！到底应该冒险展开救援让飞机迫降，还是要空中击落以遏止病毒传播全球？
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