毛大爷和毛大娘是方圆几百里地内颇有名气的外科和内科医生，他们为人善良，忠厚可亲，医德和医术颇为百姓所称道。某天清早，老两口分头外出行医。毛大娘帮人接生后在人家喝了点喜酒，醉醺醺地踏上回家之路。醉卧山间之际，竟遭遇一只斑斓猛虎。老虎毫无加害之意，反而温顺非常，原来是希望毛大娘帮其为家中的母老虎接生。看到虎宝宝顺利降生，毛大娘准备回家，临行前发现母虎受伤，于是承诺次日让擅长外科的老头儿上山疗伤。在此期间，一名商人在山上遭到劫匪残杀，而这一切也为毛家老两口的官司遭遇埋下伏笔…… 本片根据《聊斋志异》中的故事改编。
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