现场网的马楠（孙骁潇 饰）和小鱼（吴楚 饰）是一对相恋多年的情侣，马楠不久在郊外购得一处房产，刚好又赶上小鱼的生日。于是他叫来同事兼好友张博（吴超 饰）、吴晓（冯波 饰）、龙梅（王思思 饰），为小鱼策划了一次生日派对，并计划向小鱼求婚。除了曾与小鱼有过露水因缘张博外，整晚的派对都在欢快的气氛下进行。马楠家隔壁住着一对经常吵架的夫妻，异常聒噪的吵闹声引起吴晓等八卦女的好奇，她们结伴来到隔壁一探究竟，却意外发现恐怖血腥的杀人现场。 原本就住户稀少的公寓，此时仿佛变成一座巨大的鬼屋。不断闪烁的灯光，凄厉刺耳的尖叫声以及丧心病狂的杀人者。一种如瘟疫般的病毒在公寓内肆意蔓延……
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