失聪女孩佐伊（阿曼达·阿德里安 Amanda Adrienne 饰）独自驾车前往新墨西哥州，只为了见一见她深爱的男友。炎热的荒漠公路上，心情快乐的佐伊险些撞到一名受伤的印第安人，她看到一伙白人匪徒正对另一名印第安人展开杀戮，出于善良和同情，她出手相助，却让自己置身于莫大的危险之中。佐伊遭到匪徒们残酷虐待，最终更惨遭杀害，曝尸荒野。善良的印第安老人取回了佐伊的尸体，并利用千百年来流行的咒术帮她还魂。 只不过睁开双眼的佐伊，却变成了一个充满复仇怒火的恐怖魔女。血债血还，所有让她置身如此境地的邪恶之徒都将为此付出代价。
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