某个晚上，乔治和琼即将外出度过快乐的夜晚。琼特别嘱咐帮助照看小宝宝的妙龄少女珍妮，让她一定看好那个嗷嗷待哺的孩子。珍妮故作温顺，满口应承女主人的每一个要求。可是当主人刚刚关上房门，她就变了嘴脸，以迅雷不及掩耳的速度拿起电话，和朋友们大聊特聊起来，完全没将孩子放在心上。另一边厢，眼见主人外出，汤姆和杰瑞这对小伙伴无比开心，他们冲到厨房，放心自在地开起宴会。而就在此时，小宝宝偷偷爬出婴儿床，在房间内开始了惊险非常的冒险。可怜汤姆和杰瑞这两个家伙，一边吃东西的同时还要拯救处于危险境地的小婴儿，间或被珍妮误认为是欺负小孩的坏蛋殴打。 忙碌的夜晚，忙碌的小宝贝……
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